Lipedema and cellulitis are two conditions that often coexist, causing discomfort and distress to those affected. Understanding the relationship between these two conditions and implementing prevention strategies is crucial for optimal management. Lipedema is a chronic disorder characterized by an abnormal accumulation of fat in the legs and sometimes the arms, causing pain, swelling, and tenderness. On the other hand, cellulitis is a bacterial skin infection that can occur as a complication of lipedema due to impaired lymphatic drainage and weakened immune response. It presents with redness, swelling, and warmth