When most think of lipedema, they think of the changes in size the body will go through as the disproportionate fat tissue accumulates. This fat tissue is disproportionate, as it typically builds up most around the lower extremities such as the hips and thighs. This change can hurt the way you think you look and harm your social relationships. However, lipedema can do much more than just harm your self-confidence. Lipedema causes arthritic symptoms similar to that of degenerative joint disease. This condition disables most individuals, causing them mobility issues.