Project: Genetic Risk Factors and Corresponding Mechanisms Underlying Lipedema
Lipedema is a painful and debilitating condition affecting approximately 10% of adult women. It is characterized by excessive and painful fat in gynoid areas (buttocks, hips, legs) and a relatively small waist circumference. By capitalizing on multiple complementary studies, we seek to robustly identify genetic risk factors for lipedema and follow-up on specific loci by measuring gene expression levels in affected and unaffected fat tissue.
By identifying the genes that cause lipedema, we can identify physiological mechanisms that may be therapeutically acted upon, and potentially make predictions of an individual’s risk for lipedema. A better understanding of the pathways and mechanisms underlying lipedema can thus lead to improved prevention and treatment.
Dr Herbst and Dr Wright explain the Treat Study to help understand lipedema
Dr. Thomas Wright and Dr. Karen Herbst go into detail on lipedema and the Treat Study. With their expertise, you will get the inside scoop of what the top doctors of today are interested in the world of lipedema and the treatments for lipedema.
Support Lipedema Research in the USA
Dr Wright and Dr Buck are enrolling patients in a study on Lipedema. The study aims to determine the effect of weight loss on body composition and fat distribution, metabolic function (insulin sensitivity) and adipose tissue biology in women with lipedema before and after diet intervention. These results will be compared to women with obesity without lipedema. The study will last ~8-9 months and requires 5 outpatients visits and 1 inpatient visit before weight loss, and 5 outpatients visits and 1 inpatient visit after weight loss. We aim to achieve 8%-10% weight loss in ~4 months. All meals will be provided by us for the duration of the weight loss period. Study participants will be supervised weekly by our dietitian during the weight loss period.
Compensation for travel and free meal and free metabolic testing are provided for study participants.
If you are interested please contact us on the contact form or Contact Melisa Moore:
i) Diagnosis of Lipedema by Dr. Wright or Dr. Donald Buck
ii) Age ≥18 and ≤55 years;
iii) BMI ≥30.0 and <45.0 kg/m2>
i) Previous bariatric surgery or liposuction surgery
ii) Diagnosis of Type 2 Diabetes
iii) HbA1C <5.7%. iv) Structured exercise >2 days/week for ≥35 minutes of intense exercise (e.g., jogging, activity that causes heavy breathing and sweating) or ≥150 min per week of structured exercise (e.g., brisk walking)
v) Unstable weight (>4% change during the last 2 months before entering the study)
vi) Significant organ system dysfunction (e.g., diabetes, severe pulmonary, kidney or cardiovascular disease)
vii) Cancer or cancer that has been in remission for <5 years viii) Major psychiatric illness ix) Conditions that render subject unable to complete all testing procedures (e.g., severe ambulatory impairments, limb amputations, or metal implants that interfere with imaging procedures; coagulation disorders) x) Use of medications that are known to affect the study outcome measures (e.g., steroids, non-statin lipid-lowering medications) or increase the risk of study procedures (e.g., anticoagulants) and that cannot be temporarily discontinued for this study xi) Smoke cigarettes >10 cigarettes x/week
xii) Women who consume >14 units of alcohol per week
xiii) Pregnant or lactating women
xiv) Vegans, vegetarians, those with lactose intolerance and/or severe aversions/sensitivities to eggs, fish, nuts, wheat and soy, and/or any individuals with food allergies that induce an anaphylactic response
xv) Persons who are not able to grant voluntary informed consent
xvi) Persons who are unable or unwilling to follow the study protocol or who, for any reason, the research team considers not an appropriate candidate for this study, including non-compliance with screening appointments or study visits.
Instagram Star with 70 Inch Butt Diagnosed with Lipedema
A little-recognized disorder, lipedema, may be responsible, says a local expert. Lipedema makes you look like you’ve been eating too much when in fact, your fat cells are retaining fluids and growing exponentially larger than normal because of this condition.
Instagram star Randalin has is someone with lipedema who is not shy about her large hips and thighs from lipedema. In fact Randalin seems to have embraced her shape and see her curves as assets.
Maybe being fat isn’t your fault: A look at lipedema
On the tv show The Doctors, lipedema has once again come up. This time it’s with someone who’s big behind has made her a star. This isn’t the first time I’ve run into Raylynn on the internet. I came across her picture elsewhere, where people were less kind about her body type. I went to her Instagram account and could instantly tell what she had was lipedema. It’s just so obvious with the tiny waist and flat stomach. You can see her arms getting slightly bigger now too. Anyhow, on this The Doctors segment, they have plastic surgeon Dr. Andrew Ordon do a brief exam on Raylynn and he diagnosed her with this horrible condition. I’m actually excited about this particular diagnosis because she’s an internet celebrity and this is going to make some rounds. Her fans are going to talk about this episode thus talk about lipedema. I feel we’re one step closer to the right direction.
Column: The ‘Disease They Call Fat’ Misunderstood, Misdiagnosed
Koehrer is indeed struggling with extra weight. The additional pounds the 74-year-old Montgomery woman carries in her legs, thighs and midsection, however, are not the result of poor lifestyle choices but rather an incurable and chronically progressive disease that causes painful accumulations of fat which will not respond to diet or exercise.
Mikel Ruffinelli Woman With The Largest Hip In The World
Mikel Ruffinelli is a woman born 43 years ago, at first she was a normal woman like most women, has a height of 5 feet 4 inches and weighs 180 pounds. But it changed drastically when she gave birth to her first child, her weight increased 56 pounds, and strangely again the weight gain is only happening on her hips alone, then more and more often have a child for some reason hipik Mikel increasingly enlarged. And after giving birth to her fourth child the width of this woman’s waist reaches 8 feet and makes her name listed in Guinness World Records as the widest hip woman in the world. In the medical world the disorder is called lipedema.
Living With Lipedema
After receiving the diagnosis of Lipedema, all heads turn to the Internet for the glory answers of what, how, and the why. And of course, who else? You view minimal reporting from doctors and remind yourself, “That’s probably why my family doctor thought I had painful cellulite.” Yes, you are shocked, and agree to never return to a doctor who believes in such falseness. By the way, we did our research and indeed, there is no such thing as painful cellulite.
Kim Kardashian Does not have Lipedema
As a physician who diagnoses and treats lipedema, I was very concerned and disappointed in the misunderstandings and incorrect information put forward in recent National Enquirer magazine story, “Kim’s bubble butt is going to Burst”. Not only does this article’s highly exaggerated title reflect a clickbait falsehood rooted in myth and misinformation, the many claims made by the article are also completely false and highly irresponsible.
Kim’s Bubble Butt Is Going To Burst
Bottom-Heavy Kim Kardashian is battling an incurable butt disease – that could lead to her lower limbs exploding in a bloated mass of fat!
Lipedema Causing Limbs to Explode!
I saw the articles about Kim Kardashian having lipedema, what I didn’t see was that the National Enquirer claimed that her “lower limbs could explode in a bloated mass of fat.”