Dr Wright and Dr Buck are enrolling patients in a study on Lipedema. The study aims to determine the effect of weight loss on body composition and fat distribution, metabolic function (insulin sensitivity) and adipose tissue biology in women with lipedema before and after diet intervention. These results will be compared to women with obesity without lipedema. The study will last ~8-9 months and requires 5 outpatients visits and 1 inpatient visit before weight loss, and 5 outpatients visits and 1 inpatient visit after weight loss. We aim to achieve 8%-10% weight loss in ~4 months. All meals will be provided by us for the duration of the weight loss period. Study participants will be supervised weekly by our dietitian during the weight loss period.
Compensation for travel and free meal and free metabolic testing are provided for study participants.
If you are interested please contact us on the contact form or Contact Melisa Moore:
i) Diagnosis of Lipedema by Dr. Wright or Dr. Donald Buck
ii) Age ≥18 and ≤55 years;
iii) BMI ≥30.0 and <45.0 kg/m2>
i) Previous bariatric surgery or liposuction surgery
ii) Diagnosis of Type 2 Diabetes
iii) HbA1C <5.7%. iv) Structured exercise >2 days/week for ≥35 minutes of intense exercise (e.g., jogging, activity that causes heavy breathing and sweating) or ≥150 min per week of structured exercise (e.g., brisk walking)
v) Unstable weight (>4% change during the last 2 months before entering the study)
vi) Significant organ system dysfunction (e.g., diabetes, severe pulmonary, kidney or cardiovascular disease)
vii) Cancer or cancer that has been in remission for <5 years viii) Major psychiatric illness ix) Conditions that render subject unable to complete all testing procedures (e.g., severe ambulatory impairments, limb amputations, or metal implants that interfere with imaging procedures; coagulation disorders) x) Use of medications that are known to affect the study outcome measures (e.g., steroids, non-statin lipid-lowering medications) or increase the risk of study procedures (e.g., anticoagulants) and that cannot be temporarily discontinued for this study xi) Smoke cigarettes >10 cigarettes x/week
xii) Women who consume >14 units of alcohol per week
xiii) Pregnant or lactating women
xiv) Vegans, vegetarians, those with lactose intolerance and/or severe aversions/sensitivities to eggs, fish, nuts, wheat and soy, and/or any individuals with food allergies that induce an anaphylactic response
xv) Persons who are not able to grant voluntary informed consent
xvi) Persons who are unable or unwilling to follow the study protocol or who, for any reason, the research team considers not an appropriate candidate for this study, including non-compliance with screening appointments or study visits.