Lipedema, a chronic condition marked by the disproportionate accumulation of fat in the legs and arms, has perplexed and challenged the medical community for decades. Originating from the pioneering observations of Drs. Allen and Hines in 1940, the journey of lipedema treatment has evolved dramatically, from rudimentary recommendations of diet and compression stockings to groundbreaking surgical interventions. Dr. Wright’s upcoming talk with the Fat Disorders Resource Society (FDRS) from April 19-21 promises to shed light on this transformative journey and highlights the innovative strides in treating this often misunderstood disease.